Rheumatoid Arthritis B And T Cells

The effects of b cells extend beyond their roles in forming plasma cells including cytokine production direct cellular interactions and they themselves serve as antigen presenting cells to t lymphocytes.

Rheumatoid arthritis b and t cells.

B lymphocytes play several critical roles in the pathogenesis of rheumatoid arthritis. Similar to t and b cells activated macrophages produce a variety of cytokines and chemokines to support the inflammation in the. Collagen induced arthritis and the tnf transgenic mice. Immune responses potentially orchestrated by b cells in rheumatoid arthritis.

The role of t cells and their actions in rheumatoid arthritis ra has been the focus of a great deal of research for some time 1 mainly as a result of many observations in human patients and experimental animal models the association of human leukocyte antigen hla dr a mhc class ii cell surface receptor in ra provides the strongest evidence that cd4 t cells are involved in the. Cells of the synovium in rheumatoid arthritis. Müller ladner u ospelt c gay s distler o pap t. B cells are also very efficient antigen presenting cells and can contribute to t cell activation through expression of costimulatory.

B t cell interactions result in the activation and differentiation of plasma cells responsible for the production of autoantibodies in turn activated b cells provide help to t cells and induce differentiation of effector t cells that produce. Pubmed central article pubmed google scholar. As such ra is often considered the prototype disease for defining both the molecular and pathological basis of immune mediated chronic inflammatory disease and for validating targeted therapies. The multiple roles of b cells in rheumatoid arthritis.

This may be due to environmental causes genetic causes or a combination of both. Rheumatoid arthritis isn t considered a hereditary disease yet it does appear to run in families. In ra the main function of t cells is to activate macrophages and fibroblasts and transform them into tissue destructive cells. Rheumatoid arthritis ra is one of the most common chronic inflammatory syndromes.

To define the cell populations that drive joint inflammation in rheumatoid arthritis ra we applied single cell rna sequencing scrna seq mass cytometry bulk rna sequencing rna seq and flow cytometry to t cells b cells monocytes and fibroblasts from 51 samples of synovial tissue from patients with ra or osteoarthritis oa. They are the source of the rheumatoid factors and anticitrullinated protein antibodies which contribute to immune complex formation and complement activation in the joints. Here we show that b cells are enriched in the subchondral and endosteal bone marrow bm areas adjacent to osteocalcin obs in two murine ra models. These structures likely play a key role in t cell b cell.